Journal
AMERICAN JOURNAL OF ROENTGENOLOGY
Volume 207, Issue 6, Pages 1372-1379Publisher
AMER ROENTGEN RAY SOC
DOI: 10.2214/AJR.16.16545
Keywords
axillary lymph node; breast; breast cancer; radioactive seed; targeted axillary dissection; ultrasound
Funding
- National Institutes of Health, National Cancer Institute, through MD Anderson Cancer Center support grant [CA016672]
- P. H. and Fay Etta Robinson Endowed Distinguished Professorship
- Mike Hogg foundation
- MD Anderson Clinical Innovator Award
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OBJECTIVE. The purpose of this article is to describe the feasibility and safety of a multidisciplinary approach to imaging-guided axillary staging that facilitates personalized, less invasive surgical management of the axilla through targeted axillary dissection in patients with biopsy-proven nodal metastasis undergoing neoadjuvant chemotherapy. CONCLUSION. Axillary nodal status, critical in breast cancer staging, affects prognosis and treatment. As the paradigm shifts toward minimally invasive therapy, a clip marker is placed in the biopsied metastatic node for patients with N1-N2 disease undergoing neoadjuvant chemotherapy to facilitate targeted axillary dissection of the clipped node. This node is typically localized with a radioactive seed at sentinel lymph node dissection to determine whether further axillary surgery is warranted.
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