Journal
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
Volume 58, Issue 8, Pages 2991-2999Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.iecr.8b05331
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Funding
- National Natural Science Foundation of China [21776046, 21606043]
- Fundamental Research Funds for the Central Universities [2242017R30002]
- Six Talent Peaks Project in Jiangsu Province [XCL-079]
- Recruitment Program for Young Professionals (the Thousand Youth Talents Plan)
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Nanomaterials can offer a chance to integrate many excellent physical and chemical performances into a single carrier for smart responsive drug delivery. Herein, gold nanorods/mesoporous manganese dioxide (Au/MnO2) hybrid nanoparticles were prepared to combine the photothermal effect of gold nanorods (AuNRs) with glutathione (GSH)-responsive and pH-responsive performances of MnO2. The near-infrared (NIR) responsive constituent of a Au/MnO2 nanoparticle was AuNRs. Doxorubicin hydrochloride (DOX), a widely used anticancer drug, was loaded into the Au/MnO, hybrid nanoparticle via electrostatic force, hydrogen bonding, and physical absorption with a drug loading up to 99.1%. The results revealed that the mesoporous MnO, was degraded in the media with high concentrations of GSH and acid microenvironment. The Au/MnO2 nanoparticles displayed satisfying drug release kinetics (ca. 47% of loaded drug released in 12 h) and showed excellent GSH-responsive, pH-responsive, and NIR-responsive performances. This multiresponsive nanoplatform is expected to have wide biomedical application for cancer therapy such as photothermal therapy, drug delivery, and tumor microenvironment improvement.
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