GRACE score of myocardial infarction patients correlates with oxidative stress index, hsCRP and inflammation

Background: Etiopathogenesis of myocardial infarction (MI) is contributed by oxidative injury and inflammatory response. The interplay of these processes determines outcomes in MI patients. However, studies showing the relationship of oxidative stress and inflammatory cytokines with prognosis and severity of MI are lacking. Objective: The present study was designed to assess the degree of oxidative stress and inflammation in correlation with GRACE (Global Registry of Acute Coronary Events) risk score in patients of MI. Methods: MI patients were segregated according to GRACE risk score and age. Blood samples of the patients were used for determination of level of total peroxide, Total Antioxidant Status (TAS), Oxidative Stress Index (OSI), pro-inflammatory molecules such as high sensitive C-reactive protein (hsCRP), Tumor Necrosis Factor alpha (TNF alpha), interleukin 1 beta (IL 1 beta), interleukin 6 (IL 6), anti-inflammatory cytokine interleukin 10 (IL 10), and TNF alpha/IL 10 cytokine ratio. Results: We found significant elevation in concentration of total peroxide, TAS and OSI in all MI patients than healthy volunteers, this elevation showed pronouncement with higher GRACE score (GS) and age. Alteration in pro-inflammatory and anti-inflammatory cytokines was seen in MI patients than control group, and this alteration displayed polarization with GS and age. Conclusion: MI patients with higher GS and age have greater degree of OSI and inflammation, and these biochemical parameters were significantly correlated with GS and thus disease severity.