Journal
AMERICAN JOURNAL OF ROENTGENOLOGY
Volume 207, Issue 3, Pages 605-613Publisher
AMER ROENTGEN RAY SOC
DOI: 10.2214/AJR.15.15875
Keywords
autosomal dominant polycystic kidney disease; geodesic active contour; planimetry; stereology; total kidney volume
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health [P30 DK090728]
- National Cancer Institute [U01 CA160045 QIN]
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OBJECTIVE. The objective of the present study is to develop and validate a fast, accurate, and reproducible method that will increase and improve institutional measurement of total kidney volume and thereby avoid the higher costs, increased operator processing time, and inherent subjectivity associated with manual contour tracing. MATERIALS AND METHODS. We developed as emiautomated segmentation approach, known as the minimal interaction rapid organ segmentation (MIROS) method, which results in human interaction during measurement of total kidney volume on MR images being reduced to a few minutes. This software tool automatically steps through slices and requires rough definition of kidney boundaries supplied by the user. The approach was verified on T2-weighted MR images of 40 patients with autosomal dominant polycystic kidney disease of varying degrees of severity. RESULTS. The MIROS approach required less than 5 minutes of user interaction in all cases. When compared with the ground-truth reference standard, MIROS showed no significant bias and had low variability (mean +/- 2 SD, 0.19% +/- 6.96%). CONCLUSION. The MIROS method will greatly facilitate future research studies in which accurate and reproducible measurements of cystic organ volumes are needed.
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