Journal
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Volume 55, Issue 3, Pages 309-322Publisher
AMER THORACIC SOC
DOI: 10.1165/rcmb.2016-0121TR
Keywords
fibrosis; immunity; lung; T cells; neutrophils
Funding
- Deutsche Forschungsgemeinschaft, Emmy Noether Program [HA 5274/3-1]
- Collaborative Research Center/Sonderforschungsbereich (SFB) [685]
- Humboldt Foundation
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Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and progressive disease with high mortality and limited therapeutic options. Excessive deposition of extracellular matrix proteins results in fibrotic remodeling, alveolar destruction, and irreversible loss of lung function. Both innate and adaptive immune mechanisms contribute to fibrogenesis at several cellular and noncellular levels. Here, we summarize and discuss the role of immune cells (T cells, neutrophils, macrophages, and fibrocytes) and soluble mediators (cytokines and chemokines) involved in pulmonary fibrosis, pointing toward novel immune-based therapeutic strategies in the field.
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