Journal
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
Volume 25, Issue 2, Pages -Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSTQE.2018.2796132
Keywords
Photoacoustic imaging; super resolution imaging; near-field imaging; plasmonic nanoaperture
Categories
Funding
- ICT Consilience Creative Program [IITP-R0346-16-1007]
- National Research Foundation of Korea Engineering Research Center [NRF-2011-0030075]
- Korea Health Technology R&D Project of the Ministry of Health and Welfare [HI15C1817]
- Ministry of Education in Singapore [RG48/16: M4011617]
- National Research Foundation (NRF) - Korean Government [2015R1A2A1A10052826]
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Super-resolution microscopy (SRM) is becoming increasingly important to study nanoscale biological structures. Two most widely used devices for SRM are super-resolution fluorescence microscopy (SRFM) and electron microscopy (EM). For biological living samples, however, SRFM is not preferred since it requires exogenous agents andEMis not preferred since vacuum is required for sample preparation. To overcome these limitations of EM and SFRM, we present a simulation study of super-resolution photoacoustic microscopy (SR-PAM). To break the diffraction limit of light, we investigated a sub-10 nm near-field localization by focusing femtosecond laser pulses under the plasmonic nanoaperture. Using this near-field localization as a light source, we numerically studied the feasibility of the SR-PAM with a k-wave simulation toolbox in MATLAB. In this photoacoustic simulation, we successfully confirmed that the SR-PAM could be a potential method to resolve and image nanoscale structures.
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