Journal
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Volume 54, Issue 2, Pages 170-176Publisher
AMER THORACIC SOC
DOI: 10.1165/rcmb.2015-0256RC
Keywords
nontuberculous mycobacteria; Mycobacterium avium; macaque; T cells; granuloma
Funding
- Oregon National Primate Research Center core National Institute of Health [8P51 OD011092-53, AI043199]
- Nontuberculous Myocbacterium Information Resource Organization (NTMir.org)
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In this study, we sought to develop a nonhuman primate model of pulmonary Mycobacterium avium complex (MAC) disease. Blood and bronchoalveolar lavage fluid were collected from three female rhesus macaques infected intrabronchially with escalating doses of M. avium subsp. hominissuis. Immunity was determined by measuring cytokine levels, lymphocyte proliferation, and antigen-specific responses. Disease progression was monitored clinically and microbiologically with serial thoracic radiographs, computed tomography scans, and quantitative mycobacterial cultures. The animal subjected to the highest inoculum showed evidence of chronic pulmonary MAC disease. Therefore, rhesus macaques could provide a robust model in which to investigate host-pathogen interactions during MAC infection.
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