Journal
HYPERTENSION IN PREGNANCY
Volume 38, Issue 3, Pages 149-156Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10641955.2019.1597108
Keywords
Preeclampsia; vitamin D; chemerin; placenta; systolic blood pressure
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Background: Preeclampsia (PE) is a disorder of pregnancy associated with vitamin D (VD) deficiency. Chemerin is an adipokine significantly increased in preeclampsia and is regulated by VD. Objectives: To determine whether VD supplementation would protect against development of PE through Chemerin reduction Methods: PE was induced in albino rats by injection of 12.5 mg of deoxycorticosterone (DOCA). Rats were randomly divided into normal pregnant, PE group, VD supplemented PE group. Results: VD supplementation decreased systolic blood pressure, proteinuria and decreased serum Chemerin level. Conclusion: VD treatment reduced Chemerin level, and blood pressure in DOCA rat model of PE.
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