Sleep Apnea Research in Animals Past, Present, and Future

Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep. Animal models have been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animals with spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.