Journal
HAEMATOLOGICA
Volume 104, Issue 9, Pages 1731-1743Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2018.205856
Keywords
-
Categories
Funding
- National Key R&D Program of China [2017YFD0500505]
- Fundamental Research Funds for the Central Universities [KJQN201604]
- National Natural and Science Foundation of China [31500944, 81770543]
- Natural Science Foundation of Jiangsu Province [BK20170147, BK20150687]
- China Scholarship Council postdoctoral fellowship [201606855010]
- American Diabetes Association [18-IBS-167]
- NIAID [R01AId139420, R21AI140109]
Ask authors/readers for more resources
Hematopoiesis is dynamically regulated by metabolic cues in homeostatic and stressed conditions; however, the cellular and molecular mechanisms mediating the metabolic sensing and regulation remain largely obscure. Bone marrow adipose tissue remodels in various metabolic conditions and has been recently proposed as a niche for hematopoietic stem cells after irradiation. Here, we investigated the role of marrow adipose tissue-derived hematopoietic cytokine stem cell factor in unperturbed hematopoiesis by selectively ablating the Kid gene from adipocytes and bone marrow stroma cells using Adipoq-Cre and Osx1-Cre, respectively. We found that both Adipoq-Kid knockout (KO) and Osx1-Kit/ KO mice diminished hematopoietic stem and progenitor cells and myeloid progenitors in the bone marrow and developed macrocytic anemia at the steady-state. The composition and differentiation of hematopoietic progenitor cells in the bone marrow dynamically responded to metabolic challenges including high fat diet, beta 3-adrenergic activation, thermoneutrality, and aging. However, such responses, particularly within the myeloid compartment, were largely impaired in Adipoq-Kid KO mice. Our data demonstrate that marrow adipose tissue provides stem cell factor essentially for hematopoiesis both at the steady state and upon metabolic stresses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available