Journal
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Volume 257, Issue 6, Pages 1133-1140Publisher
SPRINGER
DOI: 10.1007/s00417-019-04295-1
Keywords
Diabetic retinopathy; Choroidal vasculature; Binarization; Diabetes mellitus; Diabetes duration
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BackgroundThe aim of this study was to evaluate the relationship between the choroidal structure of diabetic patients without diabetic retinopathy (DR) and duration of diabetes.MethodsThis study is a retrospective observational study in diabetic patients without DR. Eyes with diabetes mellitus (DM) (n=105) were divided into two groups based on the duration: long duration group (over 10years, n=31) and short duration group (less than 10years, n=74). One hundred seventeen eyes of non-diabetic patients were used as control group. All patients underwent enhanced depth imaging optical coherence tomography, and the choroidal structure was analyzed using a binarization method.ResultsThere was no significant difference in areas of total choroid and lumina/stroma or central choroidal thickness (CCT) between control and DM groups. In contrast, lumina/total choroidal (L/C) ratio was significantly lower in diabetic eyes than in control eyes (P=0.02). Although there was no significant difference in the areas or CCT between short and long duration groups, L/C ratio was significantly lower in the long duration group than in the short duration group (P=0.03).ConclusionsThe current study suggests that choroidal vasculature is involved in the diabetic eyes and that the choroidal structure has changed with duration of diabetes. Our study points out that L/C ratio is a new potential biomarker in monitoring choroidal vascular disorders in diabetic eyes without DR.
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