Journal
FUTURE ONCOLOGY
Volume 15, Issue 25, Pages 2933-2942Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2018-0964
Keywords
BRAF; cobimetinib; dabrafenib; ipilimumab; metastatic melanoma; nivolumab; pembrolizumab; trametinib; vemurafenib
Categories
Funding
- Novartis Pharmaceuticals Corporation East Hanover, New Jersey
Ask authors/readers for more resources
Aim: Targeted therapy (TT) and immuno-oncology (IO) drugs are approved for patients with BRAF mutant metastatic melanoma (MM). We compared real-world outcomes for first-line (1L) TT versus 1L IO to evaluate optimal sequencing. Materials & methods: Physicians-identified BRAF mutant MM patients initiating 1L TT or IO therapies and extracted treatment, disease and clinical outcomes including disease response which were compared between TT and IO and individual regimens. Results: 440 MM patients (TT = 283, IO = 157) were identified. A higher proportion of TT patients had liver metastases (46.3 vs 35.0%) and abnormal lactate dehydrogenase (61.1 vs 42.7%). IO-treated had a RECIST-determined response rate of 45.9 versus 60.1% for TT and time on treatment of 7.2 versus 11.4 months, respectively. There was no survival difference between cohorts. Conclusion: Despite higher risk patients, 1L TT resulted in higher response rate and longer treatment duration suggesting a preferred 1L sequence.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available