4.4 Article

FMO1 gene expression independently predicts favorable recurrence-free survival of classical papillary thyroid cancer

Journal

FUTURE ONCOLOGY
Volume 15, Issue 12, Pages 1303-1311

Publisher

FUTURE MEDICINE LTD
DOI: 10.2217/fon-2018-0885

Keywords

classical papillary thyroid cancer; FMO1; prognosis; RFS

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Aim: To examine the expression profile of FMO1 in papillary thyroid cancer (PTC) and its prognostic value in recurrence-free survival (RFS). Methods: A retrospective analysis was performed using data from the Cancer Genome Atlas and Human Protein Atlas. Results: The most frequent variants of PTC had decreased FMO1 expression compared with their respective adjacent normal tissues. However, even under the best cut-off model, high FMO1 expression was only significantly associated with better RFS in classical PTC (p < 0.001), but not in other two variants. High FMO1 expression independently predicted favorable RFS (hazard ratio: 0.202; 95% CI: 0.084-0.487; p < 0.001) in classical PTC. Conclusion: High FMO1 expression might serve as a biomarker that independently predicts favorable RFS in classical PTC patients.

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