Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 76, Issue 5, Pages 400-405Publisher
WILEY-BLACKWELL
DOI: 10.1111/aji.12561
Keywords
cohort study; HY-restricting HLA class II alleles; immunogenetics; recurrent pregnancy loss
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Funding
- Faculty of Health Sciences at the University of Copenhagen
- Obel Foundation
- A.P. Moller Foundation
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Problem: Women with secondary recurrent pregnancy loss (RPL) after a boy have a reduced chance of live birth in the first pregnancy after referral if they carry HY-restricting HLA class II alleles, but long-term chance of live birth is unknown. Methods of study: Live birth was compared for 540 women with unexplained secondary RPL according to firstborn's sex and maternal carriage of HLA-DRB3*03:01, HLA-DQB1*05:01/02, HLA-DRB1*15, and HLA-DRB1*07. The groups were compared by Cox proportional hazard ratios. Results: For women with at firstborn boy, maternal carriage of HY-restricting HLA class II alleles decreased chance of live birth: 0 vs 1: hazard ratio 0.75 (95% CI 0.55-1.02); 0 vs 2: HR 0.62 (0.40-0.94). Carriage of HY-restricting HLA class II alleles -decreased chance of live birth only if the firstborn was a boy: boy vs girl: HR 0.72 (95% CI 0.55-0.98). Conclusion: Maternal carriage of HY-restricting HLA class II alleles decreases long-term chance of live birth in women with RPL after a boy.
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