Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 76, Issue 2, Pages 99-107Publisher
WILEY
DOI: 10.1111/aji.12497
Keywords
BV; inflammation; pathogenesis; race; stress; vaginal epithelium
Categories
Funding
- NIH [U54MD007593, UL1TR000445]
- Meharry Translational Research Center [NIH U54 MD0007593-07]
- Tennessee Center for AIDS Research [NIH P30 AI110527]
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There is a health disparity for both bacterial vaginosis (BV) and human immunodeficiency virus type 1 (HIV-1) infection in African American women that may be linked. The evidence that BV predisposes women to higher risk for HIV infection is well documented. The underlying mechanisms to support the epidemiological connections will require further investigations. This review explores the risk factors for BV disease with implications for HIV-1 acquisition in the context of race as a potential driver of the 20-fold increase in HIV-1 acquisition for African American women compared to white women. Specifically, it explores (i) disparities for BV in African American women, (ii) racial disparity for HIV-1 acquisition in African American women, (iii) common factors associated with BV and HIV acquisition in African American women, and (iv) potential mechanisms of the enhancement of HIV-1 transmission by BV.
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