Serum Bisphenol A concentrations in men with idiopathic infertility

Background: Bisphenol A (BPA) has been associated with male reproductive dysfunction. However, few studies have assessed SPA according to the cause of male infertility. Aim To investigate serum BPA concentrations in infertile men according to infertility cause. Patients and methods: Men with infertility (n = 55) [non-obstructive azoospermia (n = 23), cryptorchidism (n = 12), varicocele (n = 20)] compared with fertile men (n = 25). Serum BPA concentrations were measured along with clinical and hormonal assessment. Results: SPA was detected in all men, with no difference between infertile and control groups [median (IQR) 0.19 (0.45) vs. 0.18 (0.28) ng/ml, p = 0.689] or among the infertility cause [azoospermia 0.30 (0.69), cryptorchidism 0.12 (0.39), varicocele 0.17 (0.23) ng/ml, p = 0.316]. High concentrations of SPA (> 3 ng/ml) were observed only in infertile men. A negative correlation was observed between BPA concentrations and AMH (r = -0.320, p < 0.01). Conclusions: Although male infertility cannot be attributed to exposure to BPA, high concentrations of SPA could contribute to infertility.