Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 125, Issue -, Pages 333-340Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2019.01.007
Keywords
Furan; Salidroside; Gut microbiota; Liver injury
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Funding
- National Natural Science Foundation of China [31471666, 31571939]
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In our study, the ameliorative effect of salidroside (SAL) from Rhodiola Rosea L on the intestinal microflora subject to furan-induced liver injury in a mouse model was investigated by 16 S rDNA, oxidative indexes, LPS and cytokine levels. The results demonstrated that SAL alleviated hepatic oxidative injury by inhibiting the activities of AST, ALT and the content of MDA, and promoting the activities of SOD, GSH and GST, compared to the furan-treated group. SAL significantly modified the intestinal microbial diversity and downregulated the circulating levels of serum LPS, IL-6, and TNF-alpha, as well as enhanced the content of IL-10. Importantly, SAL dramatically increased LPS-suppressing bacteria genera Akkermansia, and decreased LPS-producing bacteria phyla Proteobacteria. Our results indicate that SAL supplement restrains intestinal microbial dysbiosis and systemic low-grade inflammation induced by furan. Hopefully, SAL is a potential therapeutical and prophylactic compound in medicament for hepatic diseases.
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