Journal
FITOTERAPIA
Volume 133, Issue -, Pages 35-42Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.12.008
Keywords
Premna serratifolia; Lignan; Premnan Taungtangyiol; Melanogenesis enhancing activity
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI) [JP15H05138, JP17H02203, JP16H0644, JP17H05435]
- Cosmetology Research Foundation
- Kanae Foundation for The Promotion of Medical Science
- Kobayashi International Scholarship Foundation
- Takahashi Industrial and Economic Research Foundation
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Three new lignoids, premnan A (1), premnan B (2), and tauntangyiol C (3), were isolated from Premna serratifolia wood, a traditional cosmetic plant in Myanmar, together with a new lignoid, premnan C (4) assumed to be an artifact, one natural new lignoid (5), and three known lignoids (6-8). The structures of the new compounds 1-4 were elucidated based on 1D and 2D NMR, IR spectroscopy, and HRESIMS. The absolute configurations of 1-4 were also determined by optical rotation, circular dichroism (CD) data analyses, and comparisons with the reported literature. All isolated compounds were tested for their melanogenesis activities against the B16-F10 mouse melanoma cell line. Compounds 1 and 4 showed melanogenesis enhancing activities of 31% and 50%, respectively, at a 50 mu M concentration. Compounds 2, 3, and 6 increased melanin production by 67%, 30%, and 45%, respectively, at a 100 mu M concentration, without any cytotoxicity.
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