Journal
FITOTERAPIA
Volume 133, Issue -, Pages 1-4Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.11.015
Keywords
Marine derived fungus; Aspergillus versicolor; Anthraquinone dimers; Antibacterial; Cytotoxicity
Categories
Funding
- National Natural Science Foundation of China [21402100, 31800281]
- Innovation project of Jiangsu undergraduated student [201810304080Y]
- Postdoctoral Science Foundation of China [2016M591897]
- Postoctoral Science Foundation of Jiangsu Province [1601046C]
- Natural Science Foundation of Nantong City [MS12017023-3]
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As a continue investigation of the bioactive secondary metabolites from marine derived fungi, two new anthraquinone dimers (1, 2), along with three known anthraquinones (3-5) and two known xanthones (6, 7) were isolated from the marine-derived fungus Aspergillus versicolor. Their structures, including the absolute configurations, were elucidated by NMR, HRMS, and comparison with reported ones. Among them, compounds 1 and 2 were identified as anthraquinone dimers which dimerized by a rare C-O-C ether linkage, and both of them showed selective antibacterial activity against Gram-positive Staphylococcus aureus; whilst compound 6 exhibited moderate cytotoxicity against human cancer cell lines.
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