4.5 Editorial Material

A bright future for fragment-based drug discovery: what does it hold?

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Fragment-Based Drug Discovery: Advancing Fragments in the Absence of Crystal Structures

Daniel A. Erlanson et al.

CELL CHEMICAL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Identification of new allosteric sites and modulators of AChE through computational and experimental tools

Carlos Roca et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Structural Insights on Fragment Binding Mode Conservation

Malgorzata N. Drwal et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Chemistry, Multidisciplinary

Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections

Sarah L. Kidd et al.

FRONTIERS IN CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Current perspectives in fragment-based lead discovery (FBLD)

Bas Lamoree et al.

STRUCTURE-BASED DRUG DESIGN: INSIGHTS FROM ACADEMIA AND INDUSTRY (2017)

Correction Chemistry, Medicinal

When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode? (vol 60, pg 128, 2017)

Shipra Malhotra et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Chemistry, Medicinal

Multi-target Fragments Display Versatile Binding Modes

Malgorzata N. Drwal et al.

MOLECULAR INFORMATICS (2017)

Article Biochemistry & Molecular Biology

Considerations of Protein Subpockets in Fragment-Based Drug Design

Matthew Bartolowits et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2016)

Article Chemistry, Medicinal

Identifying Interactions that Determine Fragment Binding at Protein Hotspots

Chris J. Radoux et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Chemistry, Medicinal

Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design

Christiane Ehrt et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Review Biotechnology & Applied Microbiology

Twenty years on: the impact of fragments on drug discovery

Daniel A. Erlanson et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Multidisciplinary Sciences

Detection of secondary binding sites in proteins using fragment screening

R. Frederick Ludlow et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Pharmacology & Pharmacy

Lessons from Hot Spot Analysis for Fragment-Basec Drug Discovery

David R. Hall et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2015)

Review Biochemistry & Molecular Biology

Efficient exploration of chemical space by fragment-based screening

Richard J. Hall et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2014)

Article Chemistry, Medicinal

Thermodynamics of Fragment Binding

Gyoergy G. Ferenczy et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)