Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2019, Issue 17, Pages 2812-2818Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201900237
Keywords
PIFA; TMSCl; Arenes; Electrophilic chlorination; I(III) species
Categories
Funding
- Spain's MICINN [CTQ2014-53662-P]
- MEC [CTQ2016-81797-REDC]
- DURSI-Generalitat de Catalunya [2017-SGR465]
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Efficient metal-free methods for the electrophilic chlorination of arenes using PIFA and simple chlorine sources are reported. The in situ formation of PhI(Cl)OCOCF3 from PIFA and KCl is proposed, which resulted in a chlorinating species for moderately activated arenes. Moreover, the in situ formation of PhICl2 from PIFA and TMSCl resulted in an excellent approach for the chlorination of a great variety of arenes (20 examples) in high yields, even when working on a multigram scale.
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