4.5 Article

Iron-Catalyzed Minisci Type Acetylation of N-Heteroarenes Mediated by CH(OEt)3/TBHP

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2019, Issue 8, Pages 1815-1819

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201900033

Keywords

Acetylation; Iron catalyst; N-heteroarenes; Triethylorthoformate; TBHP

Funding

  1. CSIR-India
  2. UGC-India
  3. DST-India
  4. IFCPAR - India (CEFIPRA) [5305-1]

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Iron-catalyzed acetylation of electron deficient N-heteroarenes has been reported using triethylorthoformate as robust and inexpensive acetyl source. This new method is successfully applied for the acetylation of quinolines, isoquinoline, quinoxalines, arylpyridines, bipyridines, and benzothiazole.

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