Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 166, Issue -, Pages 206-223Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.01.047
Keywords
Triazole; Hybrid compounds; Antiplasmodial; Antimalarial; Structure-activity relationship
Categories
Funding
- National Natural Science Foundation of China [81803423]
- Natural Science Foundation of Zhejiang [LQ18D060005]
- China Scholarship Council-Local cooperation project [201808330623]
- Specific research project of Guangxi for research bases and talents [Guike AD18126005]
- Natural Science Foundation of Shandong [ZR2018BB024]
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Malaria, caused by protozoan parasites of the genus Plasmodium especially by the most prevalent parasite Plasmodium falciparum, represents one of the most devastating and common infectious disease globally. Nearly half of the world population is under the risk of being infected, and more than 200 million new clinical cases with around half a million deaths occur annually. Drug therapy is the mainstay of antimalarial therapy, yet current drugs are threatened by the development of resistance, so it's imperative to develop new antimalarials with great potency against both drug-susceptible and drug resistant malaria. Triazoles, bearing a five-membered heterocyclic ring with three nitrogen atoms, exhibit promising in vitro antiplasmodial and in vivo antimalarial activities. Moreover, several triazole-based drugs have already used in clinics for the treatment of various diseases, demonstrating the excellent pharmaceutical profiles. Therefore, triazole derivatives have the potential for clinical deployment in the control and eradication of malaria. This review covers the recent advances of triazole derivatives especially triazole hybrids as potential antimalarials. The structure-activity relationship is also discussed to provide an insight for rational designs of more efficient antimalarial candidates. (C) 2019 Elsevier Masson SAS. All rights reserved.
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