Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 69, Issue -, Pages 57-65Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2019.03.019
Keywords
Polystyrene; In vitro; Human pharmaceuticals; Combined exposures
Funding
- CESAM [UID/AMB/50017/2019]
- FCT/MCTES
- FEDER
- FEDER, within Compete 2020
- program Investigador FCT [IF/00335/2015]
- Human Potential Operational Program
- European Social Fund
Ask authors/readers for more resources
There is an increasing concern on the consequences of the presence of micro(nano)plastics to marine organisms. The present study aimed to provide information on the effects of polystyrene nanoplastics (PSNPs) to fish cells alone and combined with human pharmaceuticals, other emerging contaminants, using as biological models marine fish cell lines SAF-1 and DLB-1. Cells were exposed for 24 h to 100 tun PSNPs, starting at 0.001 up to 10 mg/L, to assess effects on viability and activity of catalase (antioxidant defense) and glutathione S-trans-ferases (phase II biotransformation and antioxidant defense). The viability of cells was also evaluated after exposure to human pharmaceuticals alone and combined with PSNPs. Overall, PSNPs failed to be cytotoxic but data proved their ability to alter the toxicity of human pharmaceuticals. DLB-1 was the most sensitive cell line to PSNPs. Data support the use of marine fish cell lines in the study of the effects of micro(nano)plastics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available