Journal
ENVIRONMENTAL POLLUTION
Volume 245, Issue -, Pages 590-599Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2018.11.031
Keywords
Insecticides; Pyrethroids; Endocrine-disrupting chemicals; Hypothalamic-pituitary-gonadal axis; Reproductive health
Categories
Funding
- National Natural Science Foundation of China [21876151]
- Zhejiang Provincial Natural Science Foundation of China [LR15B070001]
- Zhejiang University K. P. Chao's High Technology Development Foundation
Ask authors/readers for more resources
Pyrethroids, a class of ubiquitous insecticides, have been recognized as endocrine-disrupting chemicals (EDCs). A lot of studies have implied the endocrine-disrupting effects of pyrethroids on the hypothalamic-pituitary-gonadal (HPG) axis. However, there are few review articles regarding the effects of pyrethroids on the HPG axis of mammal and human, especially new research progress made in this area. The present review sums up the effects of pyrethroids on the HPG axis-related reproductive outcomes, including epidemiological investigations based on human biomonitoring, animal studies and in vitro tests. Mechanisms have described that the endocrine-disrupting effects of pyrethroids on mammal can be mediated via the interaction with steroid receptors, the direct action on ion channels and signaling molecules. Finally, we summarize the current research gaps and suggest future directions in this topic. (C) 2018 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available