Journal
ENVIRONMENTAL POLLUTION
Volume 246, Issue -, Pages 597-607Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2018.12.077
Keywords
Mice oocyte; Meiosis; Dibutyl phthalate; Spindle; Cytoskeletons
Categories
Funding
- National Key Research and Development Program of China [2017YFD0501905]
- National Natural Science Foundation of China [31672248, 31772407]
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Di(n-butyl) phthalate (DBP) is extensively used in industrial applications as plasticizer and stabilizer and its presence in the environment may present health risks for human. Previous studies have demonstrated its mutagenic, teratogenic, and carcinogenic ability. However, its effect on mammalian oocyte maturation remains unknown. In this study, we examined the effect of DBP on oocyte maturation both in vitro and in vivo. Our results showed that DBP could significantly reduce mice oocyte germinal vesicle breakdown (GVBD) and polar body extrusion (PBE) rates. In addition, oocyte cytoskeleton was damaged and cortical granule-free domains (CGFDs) were also disrupted. Finally, DBP induced early apoptosis of oocyte and granulosa cells (GCs). Collectively, these data demonstrate that DBP could reduce meiosis competence and mouse oocyte development. (C) 2018 Published by Elsevier Ltd.
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