Journal
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Volume 311, Issue 5, Pages L924-L927Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajplung.00355.2016
Keywords
lung development; lung injury; animal models; infant; premature; diseases; bronchopulmonary dysplasia
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Funding
- NIH [U01 HL122626, R01 HL129907, R01 HD067126]
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There have been many efforts to develop good animal models of bronchopulmonary dysplasia (BPD) to better understand the pathophysiology and mechanisms underlying development of BPD as well as to test potential strategies for its prevention and treatment. This Perspectives summarizes the features of common animal models of BPD and the strengths and limitations of such models. Potential optimal approaches to development of animal models are indicated, with the underlying concepts that require emphasis.
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