Journal
EMBO REPORTS
Volume 20, Issue 4, Pages -Publisher
WILEY
DOI: 10.15252/embr.201847129
Keywords
circadian; diurnal; microbiome; rhythm
Categories
Funding
- Early Postdoctoral Fellowship of the Swiss National Science Foundation
- EMBO Long-term Fellowship
- Abisch Frenkel Foundation for the Promotion of Life Sciences
- Gurwin Family Fund for Scientific Research
- Leona M. and Harry B. Helmsley Charitable Trust
- Crown Endowment Fund for Immunological Research
- Else Kroener Fresenius Foundation
- estate of J. Gitlitz
- estate of L. Hershkovich
- Benoziyo Endowment Fund for the Advancement of Science
- Adelis Foundation
- French National Center for Scientific Research (CNRS)
- V.R. Schwartz Research Fellow Chair
- European Research Council
- Marie Curie Integration grant
- German-Israeli Foundation for Scientific Research and Development
- Israel Science Foundation
- Minerva Foundation
- Rising Tide Foundation
- Helmholtz Foundation
- European Foundation for the Study of Diabetes
Ask authors/readers for more resources
Host-microbiome interactions constitute key determinants of host physiology, while their dysregulation is implicated in a wide range of human diseases. The microbiome undergoes diurnal variation in composition and function, and this in turn drives oscillations in host gene expression and functions. In this review, we discuss the newest developments in understanding circadian host-microbiome interplays, and how they may be relevant in health and disease contexts. We summarize the molecular mechanisms by which the microbiome influences host function in a diurnal manner, and inversely describe how the host orchestrates circadian rhythmicity of the microbiome. Furthermore, we highlight the future perspectives and challenges in studying this new and exciting facet of host-microbiome interactions. Finally, we illustrate how the elucidation of the microbiome chronobiology may pave the way for novel therapeutic approaches.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available