Journal
EMBO JOURNAL
Volume 38, Issue 8, Pages -Publisher
WILEY
DOI: 10.15252/embj.2018100941
Keywords
antiviral immunity; Dicer; double-stranded RNA; interferons; RNA interference
Categories
Funding
- Francis Crick Institute - Cancer Research UK [FC001136]
- UK Medical Research Council [FC001136]
- Wellcome Trust [FC001136, WT106973MA]
- ERC [AdG 786674]
- Wolfson UCL
- EMBO
Ask authors/readers for more resources
To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell-intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA-based mechanism, for cell-intrinsic immunity to viruses while vertebrates rely on the protein-based interferon (IFN)-driven innate immune system for the same purpose. The RNAi machinery is conserved in vertebrate cells, yet whether antiviral RNAi is still active in mammals and functionally relevant to mammalian antiviral defence is intensely debated. Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available