Journal
ELECTRONIC JOURNAL OF BIOTECHNOLOGY
Volume 38, Issue 1, Pages 49-57Publisher
UNIV CATOLICA DE VALPARAISO
DOI: 10.1016/j.ejbt.2019.01.001
Keywords
Acidithlobacillus ferrooxidans; Bioleaching; Cancer; Chinese medicine; Dissolvability; Extremophilic bacterium; Leukemia; Mineral medicine; Nanoparticles; Nanotechnology; Realgar
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Funding
- Technology Program of Gansu Province [1604FKCA110]
- Fundamental Research Funds for the Central Universities of China [lzujbky-2017-197]
- Project of Lanzhou City for Innovative and Entrepreneurial Talents [2017-RC-73]
- Science and Technology Project of Lanzhou City [2015-3-93, 2016-3-75, 2017-4-122, 2018-04-59]
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Background: This paper presents micro- and nano-fabrication techniques for leachable realgar using the extremophilic bacterium Acidithiobacillus ferrooxidans (A. ferrooxidans) DLC-5. Results: Realgar nanopartides of size ranging from 120 nm to 200 nm were successfully prepared using the high-energy ball mill instrument. A. ferrooxidans DLC-5 was then used to bioleach the particles. The arsenic concentration in the bioleaching system was found to be increased significantly when compared with that in the sterile control. Furthermore, in the comparison with the bioleaching of raw realgar, nanoparticles could achieve the same effect with only one fifth of the consumption. Conclusion: Emphasis was placed on improving the dissolvability of arsenic because of the great potential of leachable realgar drug delivery in both laboratory and industrial settings. (C) 2019 Pontificia Universidad Catolica de Valparaiso. Production and hosting by Elsevier B.V. All rights reserved.
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