Journal
ELECTROANALYSIS
Volume 31, Issue 5, Pages 829-837Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201800798
Keywords
Solvothermal; Methotrexate; Fe3O4 Nanoparticles; ITO; Electrochemical Sensors; Blood Serum; Square wave voltammetry
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Here, we reported on a one-step fabrication of magnetite Fe3O4 nanoparticles/indium tin oxide (ITO) electrode based on the direct growing of Fe3O4 nanoparticles on the ITO surface by using a solvothermal process. The modified electrode was used as electrochemical methotrexate (MTX) biosensor with high sensitivity based on cyclic voltammetry and square wave voltammetry techniques. The results demonstrated a linear relationship between the MTX concentration and its oxidation current peak over a wide range from 10(-5) to 10(-14) mole/L with a limit of detection of 0.4x10(-15) M based on the square wave voltammetry (SWV) technique. In addition, Fe3O4/ITO electrode showed a good capability for measuring very low concentrations of MTX drug dissolved in human serum solution. Also, Fe3O4/ITO electrode was used for detecting MTX in blood serum samples collected from patients after their treatment with MTX. The prepared electrode showed the higher sensitivity that higher than the Viva-E instrument, which opens the door for developing a cheap, simple and higher sensitive MTX sensor.
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