Journal
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Volume 310, Issue 3, Pages H365-H375Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00562.2015
Keywords
aging; cerebrovascular circulation; remodeling; vasculature
Funding
- National Heart, Lung, and Blood Institute [PO1-HL-070687]
- Jackson and American Heart Association [13GRNT17210000]
- National Institutes of Health [5T32-GM-092715-04]
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Artery remodeling, described as a change in artery structure, may be responsible for the increased risk of cardiovascular disease with aging. Although the risk for stroke is known to increase with age, relatively young animals have been used in most stroke studies. Therefore, more information is needed on how aging alters the biomechanical properties of cerebral arteries. Posterior cerebral arteries (PCAs) and parenchymal arterioles (PAs) are important in controlling brain perfusion. We hypothesized that aged (22-24 mo old) C57bl/6 mice would have stiffer PCAs and PAs than young (3-5 mo old) mice. The biomechanical properties of the PCAs and PAs were assessed by pressure myography. Data are presented as means +/- SE of young vs. old. In the PCA, older mice had increased outer (155.6 +/- 3.2 vs. 169.9 +/- 3.2 mu m) and lumen (116.4 +/- 3.6 vs. 137.1 +/- 4.7 mu m) diameters. Wall stress (375.6 +/- 35.4 vs. 504.7 +/- 60.0 dyn/cm(2)) and artery stiffness (beta-coefficient: 5.2 +/- 0.3 vs. 7.6 +/- 0.9) were also increased. However, wall strain (0.8 +/- 0.1 vs. 0.6 +/- 0.1) was reduced with age. In the PAs from old mice, wall thickness (3.9 +/- 0.3 vs. 5.1 +/- 0.2 mu m) and area (591.1 +/- 95.4 vs. 852.8 +/- 100 +/- mu m(2)) were increased while stress (758.1 +/- 100.0 vs. 587.2 +/- 35.1 dyn/cm2) was reduced. Aging also increased mean arterial and pulse pressures. We conclude that age-associated remodeling occurs in large cerebral arteries and arterioles and may increase the risk of cerebrovascular disease.
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