Journal
DRUG DISCOVERY TODAY
Volume 24, Issue 8, Pages 1446-1457Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2019.02.001
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Funding
- Government of Russian Federation Mega-Grant [14.W03.031.0025]
- Lundbeck Foundation [R181-2014-3577]
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie [799880]
- Marie Curie Actions (MSCA) [799880] Funding Source: Marie Curie Actions (MSCA)
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Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.
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