4.3 Review

The role of extracellular matrix on liver stem cell fate: A dynamic relationship in health and disease

Journal

DIFFERENTIATION
Volume 106, Issue -, Pages 49-56

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.diff.2019.03.001

Keywords

Liver development; ECM; Stem cell; Progenitor cell; Stem cell niche; Growth factors; Mechanobiology

Funding

  1. Gobierno de Aragon [DGA C066/2014]
  2. Fondo Social Europeo [DGA C066/2014]
  3. Instituto de Salud Carlos III [i-PFIS IFI15/00158]
  4. POCTEFA/Refbio II research grant
  5. Instituto de Salud Carlos III, Spain [PI15/00563]

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The liver stem cell niche is a specialized and dynamic microenvironment with biomechanical and biochemical characteristics that regulate stem cell behavior. This is feasible due to the coordination of a complex network of secreted factors, small molecules, neural, blood inputs and extracellular matrix (ECM) components involved in the regulation of stem cell fate (self-renewal, survival, and differentiation into more mature phenotypes like hepatocytes and cholangiocytes). In this review, we describe and summarize all the major components that play essential roles in the liver stem cell niche, in particular, growth factor signaling and the biomechanical properties of the ECM.

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