4.3 Article

Emergence of colistin resistance during treatment of recurrent pneumonia caused by carbapenemase producing Klebsiella pneumoniae

Journal

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 94, Issue 4, Pages 407-409

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2019.02.014

Keywords

Colistin resistance; ST15; K. pneumoniae; Carbapenemase producing Enterobactericeae

Funding

  1. University of Antwerp [BOF-DOCPRO 2012-27450]

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A 60-year-old woman received meropenem/colistin treatment for bilateral pneumonia caused by a ST15 carbapenemase producing Klebsiella pneumoniae. The patient recovered but re-infection with the same (ST15), but now colistin-resistant K. pneumoniae. occurred. The molecular mechanism of the emerged colistin resistance was identified as mgrB gene modification by insertion element (IS) IS903B. (C) 2019 Elsevier Inc. All rights reserved.

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