Journal
DIABETES TECHNOLOGY & THERAPEUTICS
Volume 21, Issue 3, Pages 128-132Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/dia.2018.0374
Keywords
Continuous glucose monitoring; Dexcom G5; Dexcom G6; Propensity scoring; Real-world evidence
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Background: Accuracy and feature sets of continuous glucose monitoring (CGM) systems may influence device utilization and outcomes. We compared clinical trial accuracy and real-world utilization and effectiveness of two different CGM systems. Materials and Methods: Separately conducted accuracy studies of a fifth-generation and a sixth-generation CGM system involved 50 and 159 adults, respectively. For between-system performance comparisons, propensity score methods were utilized to balance cohort characteristics. Real-world outcomes were assessed in 10,000 anonymized patients who had switched from the fifth-generation to the sixth-generation system and had used connected mobile devices to upload data from both systems, allowing pairwise comparisons of device utilization and glucose concentration distributions. Results: Propensity score-adjusted mean absolute relative differences for the fifth- and sixth-generation systems were 9.0% and 9.9%, and the percentages of values within 20%/20mg/dL were 93.1% and 92.5%, respectively. The sixth-generation system, but not the fifth-generation system, met accuracy criteria for interoperable CGM systems. Both systems had high real-world utilization rates (93.8% and 95.3% in the fifth- and sixth-generation systems, respectively). Use of the sixth-generation system was associated with fewer glucose values <55mg/dL (<3.1mmol/L) (0.7% vs. 1.1%, P<0.001) and more values 70-180mg/dL (3.9-10.0mmol/L) (57.3% vs. 56.0%, P<0.001) than the fifth-generation system. Conclusions: CGM performance outcomes can be compared through the propensity score analysis of clinical trial data and pairwise comparisons of real-world data. The systems compared here had nearly equivalent accuracy and utilization rates. Longer term biochemical and psychosocial benefits observed with the fifth-generation system are also expected with the sixth-generation system.
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