4.5 Article

Effect of canagliflozin on the overall clinical state including insulin resistance in Japanese patients with type 2 diabetes mellitus

Journal

DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 149, Issue -, Pages 140-146

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2019.01.029

Keywords

Canagliflozin; SGLT2; Type 2 diabetes; Insulin resistance; Glucose clamp; Visceral fat

Funding

  1. Mitsubishi Tanabe Pharma Corporation (Osaka, Japan)

Ask authors/readers for more resources

Aims: Information on the clinical efficacy of SGLT2 inhibitors in the Japanese population is limited. The aim of this single-arm, single-center, open-label study was to confirm the body weight-and fat mass-lowering effects of canagliflozin (CANA) and the accompanying improvement in insulin resistance in Japanese patients with Type 2 diabetes mellitus (T2DM). Methods: Thirty-eight patients were enrolled and administered 100 mg CANA once daily for 24 weeks. Blood and anthropometric parameters were examined before and after treatment. In a subset of patients, insulin sensitivity was assessed based on the glucose infusion rate (GIR) during a hyperinsulinemic euglycemic clamp test. Results: CANA treatment significantly decreased hemoglobin A1c, fasting plasma glucose, and plasma liver enzyme levels, and increased plasma adiponectin levels. In addition, a significant reduction in body weight, visceral and subcutaneous fat area, fat and lean mass, and liver steatosis was also observed. The change in plasma adiponectin levels significantly correlated with the changes in both body fat mass and visceral fat area. GIR increased from 3.25 +/- 1.53 to 4.11 +/- 1.30 mg/kg/min (P < 0.05). Conclusions: CANA improved insulin resistance and decreased visceral fat mass in Japanese patients with T2DM. (C) 2019 The Authors. Published by Elsevier B.V.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available