Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 148, Issue -, Pages 160-168Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2019.01.009
Keywords
Omentin; Adipokine; Endothelial function; Flow-mediated dilatation; Type 2 diabetes
Categories
Funding
- Japan Society for the Promotion of Science [20591068]
- Novartis Pharma Research Grants 2017
Ask authors/readers for more resources
Aims: Omentin is an adipokine that has protective effects against cardiovascular damage. Previous studies showed an inverse relationship between omentin and obesity, diabetes, and cardiovascular disease. This study aimed to investigate the association between omentin and vascular endothelial function in patients with type 2 diabetes (T2D). Methods: The subjects were 425 patients with T2D and 223 non-diabetic controls. Fasting plasma omentin levels were measured by enzyme-linked immunosorbent assay, and the endothelium-dependent, flow-mediated dilatation (FMD) wasmeasured by ultrasonography. Results: Plasma omentin levels were higher, while FMD was lower in participants with T2D than in non-diabetic controls. No significant correlation was found between plasma omentin levels and FMD in either non-diabetic controls or participants with T2D on multivariate analysis. However, stratified analysis in T2D patients revealed that plasma omentin levels were independently and positively associated with FMD in high cardiovascular risk subgroups according to age (>= 65 years), estimated glomerular filtration rate (<60 mL/min/1.73m2), or preexisting cardiovascular diseases but not in low-risk subgroups. Conclusions: Plasma omentin levels are independently associated with endothelial function in subgroups of patients with T2D at elevated cardiovascular risk. This study suggests a protective role of omentin against endothelial dysfunction, particularly in high-risk patients. (C) 2019 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available