Journal
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Volume 310, Issue 11, Pages G1081-G1090Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00026.2016
Keywords
nuclear factor-kappa B; gastric cancer; Helicobacter pylori; colitis
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Funding
- European Union [305564]
- North West Cancer Research grant
- Physiological Society
- Fiona Elizabeth Agnew Trust
- BSG/CORE development award
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Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett's esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-kappa B signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-kappa B signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-kappa B signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development.
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