Journal
DEVELOPMENTAL BIOLOGY
Volume 449, Issue 1, Pages 35-40Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2019.02.004
Keywords
Cochlea; Inner ear; Eph receptor; Ephrin; Development; Hearing
Categories
Funding
- Belgian Fonds de la Recherche Scientifique - FNRS
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In mammals, the functional development of the cochlea requires the tight regulation of multiple molecules and signalling pathways including fibroblast growth factors, bone morphogenetic proteins, Wnt and Notch signalling pathways. Over the last decade, the Eph/ephrin system also emerged as a key player of the development and function of the mammalian cochlea. In this review, we discuss the recent advances on the role of Eph/ephrin signalling in patterning the cochlear sensory epithelium and the complex innervation of mechanosensory hair cells by spiral ganglion neurons. Finally, we address the issue of a syndromic form of hearing loss caused by a deficient member of the Eph/ephrin family.
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