Journal
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Volume 310, Issue 9, Pages G629-G644Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00201.2015
Keywords
gastrointestinal cancer; chemoprevention; phytoprevention; natural products; late-stage cancer
Categories
Funding
- National Institutes of Health [R01CA96694]
- Cancer Center Support Grant [P30CA054174]
- Kronkosky Foundation
Ask authors/readers for more resources
The last decade has witnessed remarkable progress in the utilization of natural products for the prevention and treatment of human cancer. Many agents now in the pipeline for clinical trial testing have evolved from our understanding of how human nutritional patterns account for widespread differences in cancer risk. In this review, we have focused on many of these promising agents arguing that they may provide a new strategy for cancer control: natural products once thought to be only preventive in their mode of action now are being explored for efficacy in tandem with cancer therapeutics. Natural products may reduce off-target toxicity of therapeutics while making cancers more amenable to therapy. On the horizon is the use of certain natural products, in their own right, as mitigants of late-stage cancer, a new frontier for small-molecule natural product drug discovery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available