Journal
CURRENT TREATMENT OPTIONS IN ONCOLOGY
Volume 20, Issue 4, Pages -Publisher
SPRINGER
DOI: 10.1007/s11864-019-0631-8
Keywords
Oral cavity squamous cell carcinoma; Treatment; Primary chemoradiotherapy; Immunotherapy; Neoadjuvant therapy; Outcome
Categories
Ask authors/readers for more resources
Opinion statementAt our institution, locally advanced oral cancer is most commonly treated with surgical resection, immediate reconstruction, and adjuvant radiotherapy with or without concurrent systemic therapy depending on final surgical pathologic analysis. There are patients with markedly advanced local or regional disease who unfortunately will have a low probability of cure. We counsel these patients on induction chemotherapy, emphasizing that this is unlikely to result in a smaller volume of surgical resection. In these patients, a good response to induction chemotherapy is more frequently followed by concurrent chemoradiotherapy. We have not been in the practice of commonly recommending definitive chemoradiotherapy for locally advanced oral cancer when upfront surgery is an option. However, as reviewed below, there is a significant rationale for definitive chemoradiotherapy in patients who are surgical candidates, with the hope of good oncologic outcomes, and potential functional organ preservation. The experts who report their experiences in the studies reviewed below provide a strong argument for considering this approach.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available