4.5 Review

Photo- and Sono-Dynamic Therapy: A Review of Mechanisms and Considerations for Pharmacological Agents Used in Therapy Incorporating Light and Sound

Journal

CURRENT PHARMACEUTICAL DESIGN
Volume 25, Issue 4, Pages 401-412

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612825666190123114107

Keywords

Photodynamic therapy; sonodynamic therapy; sono-photodynamic therapy; perfluorocarbon; photosensitizer; sonosensitier; ultrasound contrast agents

Funding

  1. National Natural Science Foundation of China [81627802, 81503299, 81527803, 81420108018, 11774166, 11774168, 11674173, 11874216]
  2. QingLan Project
  3. Fundamental Research Funds for the Central Universities [020414380109, 020414380113]

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As irreplaceable energy sources of minimally invasive treatment, light and sound have, separately, laid solid foundations in their clinic applications. Constrained by the relatively shallow penetration depth of light, photodynamic therapy (PDT) typically involves involves superficial targets such as shallow seated skin conditions, head and neck cancers, eye disorders, early-stage cancer of esophagus, etc. For ultrasound-driven sonodynamic therapy (SDT), however, to various organs is facilitated by the superior... transmission and focusing ability of ultrasound in biological tissues, enabling multiple therapeutic applications including treating glioma, breast cancer, hematologic tumor and opening blood-brain-barrier (BBB). Considering the emergence of theranostics and precision therapy, these two classic energy sources and corresponding sensitizers are worth reevaluating. In this review, three typical therapies using light and sound as a trigger, PDT, SDT, and combined PDT and SDT are introduced. The therapeutic dynamics and current designs of pharmacological sensitizers involved in these therapies are presented. By introducing both the history of the field and the most up-to-date design strategies, this review provides a systemic summary on the development of PDT and SDT and fosters inspiration for researchers working on 'multi-modal' therapies involving light and sound.

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