Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 55, Issue -, Pages 81-86Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2018.08.009
Keywords
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Funding
- European Union's Horizon 2020 Research and Innovation Programme [685817]
- Austrian Research Promotion Agency (EEG) [1849791]
- EU joint Programme - Neurodegenerative Disease Research (JPND) [3DPD] [735840]
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Organ-on-a-chip technology offers the potential to recapitulate human physiology by keeping human cells in a precisely controlled and artificial tissue-like microenvironment. The current and potential advantages of organs-on-chips over conventional cell cultures systems and animal models have captured the attention of scientists, clinicians and policymakers as well as advocacy groups in the past few years. Recent advances in tissue engineering and stem cell research are also aiding the development of clinically relevant chip based organ and diseases models with organ level physiology for drug screening, biomedical research and personalized medicine. Here, the latest advances in organ-on-a-chip technology are reviewed and future clinical applications discussed.
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