Journal
CURRENT MEDICINAL CHEMISTRY
Volume 27, Issue 20, Pages 3362-3385Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867326666190212121248
Keywords
Mitochondria associated membranes; endoplasmic reticulum; mitochondria; calcium ions; insulin resistance; T2DM
Funding
- University Grants Commission, Govt. of India [21/06/2015(i) EU-V]
- Department of Health Research (DHR), Govt. of India [R.12014/11/2017-HR, R.12014/17/2017-HR]
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MAMs, the physical association between the Endoplasmic Reticulum (ER) and mitochondria are, functional domains performing a significant role in the maintenance of cellular homeostasis. It is evolving as an important signaling center that coordinates nutrient and hormonal signaling for the proper regulation of hepatic insulin action and glucose homeostasis. Moreover. MAMs can be considered as hot spots for the transmission of stress signals from ER to tnitochondria. The altered interaction between ER and mitochondria results in the amendment of several insulin-sensitive tissues, revealing the role of MAMs in glucose homeostasis. The development of mitochondria] dysfunction, ER stress, altered lipid and Ca2+ homeostasis are typically co-related with insulin resistance and f cell dysfunction. But little facts are known about the role played by these stresses in the development of metabolic disorders. In this review, we highlight the mechanisms involved in maintaining the contact site with new avenues of investigations for the development of novel preventive and therapeutic targets for T2DM.
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