Journal
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Volume 310, Issue 7, Pages C509-C519Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00364.2015
Keywords
STIM; ORAI; Ca2+; cancer
Categories
Funding
- INSERM, Ligue National Contre le Cnacer, Region Nord Pas-de-Calais, Ministere de l'Education National, France
- University of Torino, Compagnia di S Paolo
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Intracellular Ca2+ signals play a central role in several cellular processes; therefore it is not surprising that altered Ca2+ homeostasis regulatory mechanisms lead to a variety of severe pathologies, including cancer. Stromal interaction molecules (STIM) and ORAI proteins have been identified as critical components of Ca2+ entry in both store-dependent (SOCE mechanism) and independent by intracellular store depletion and have been implicated in several cellular functions. In recent years, both STIMs and ORAIs have emerged as possible molecular targets for cancer therapeutics. In this review we focus on the role of STIM and ORAI proteins in cancer progression. In particular we analyze their role in the different hallmarks of cancer, which represent the organizing principle that describes the complex multistep process of neoplastic diseases.
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