Journal
COORDINATION CHEMISTRY REVIEWS
Volume 380, Issue -, Pages 230-259Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2018.09.009
Keywords
Metal-organic frameworks; Drug delivery; Zirconium; Biomedicine; In vivo; In vitro; Imaging
Categories
Funding
- Royal Society
- University of Glasgow
- European Research Council (ERC) under the European Union's Horizon 2020 Programme for Research and Innovation [677289]
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Nanoparticulate metal-organic frameworks (MOFs) have the requisite high storage capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for application as nanoscale drug delivery devices (DDSs). Zirconium MOFs in particular combine optimal stability towards hydrolysis and postsynthetic modification with low toxicity, and so are particularly suited for biological applications. This review covers the use of Zr MOFs as DDSs with focus on the different physical properties that makes them attractive for use. The various methods for modifying the surfaces of Zr MOFs are described with pertinent examples of the resulting enhancements in aqueous stability, colloidal dispersion, and stimuli-responsive drug release. The in vitro and in vivo application of Zr MOFs for photodynamic therapy and drug delivery are discussed with respect to the structural features of the MOFs and their surface functionality, and perspectives on their future applications and analogous hafnium MOFs are given. (C) 2018 Elsevier B.V. All rights reserved.
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