Journal
COORDINATION CHEMISTRY REVIEWS
Volume 382, Issue -, Pages 160-180Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2018.12.015
Keywords
Ferroptosis therapy; Fenton reaction; Mechanism; Cancer; Nanomaterial; Reactive oxygen species
Categories
Funding
- NSF of China [81771976, 61527806]
- National Key Research and Development Program of China [2017YFA0205301]
- Open Funding of State Key Laboratory of Oral Diseases [SKLOD2018OF02]
- Joint Funds of Nanjing Medical University and Southeast University [2017DN19]
- Excellent Young Teachers Program of Nanjing Medical University [2015RC11]
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Ferroptosis is a new form of nonapoptotic programmed cell death characterized by iron-dependent accumulation of lipid hydroperoxides to lethal levels. An increasing number of studies have in recent years revealed close relationships between ferroptosis and nanomedicine, which has been regarded as a new strategy for developing nanomaterial-based therapeutic agents for highly effective therapy of various cancers. In this review, the molecular mechanisms and pathways for ferroptosis regulation were first presented; then, various nanomaterials that induce ferroptosis for cancer specific therapy were systematically discussed; finally, the current challenges and constructive perspectives in this field were provided. (C) 2018 Elsevier B.V. All rights reserved.
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