Journal
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
Volume 22, Issue 5, Pages 518-532Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10255842.2019.1567720
Keywords
Liver cancer; B-TACE; haemodynamics; computational fluid dynamics; 0D modelling; 3D modelling
Funding
- TERUMO EUROPE, NV (Leuven, Belgium)
- Ministerio de Economia y Competitividad (Spanish Government) [DPI2015-68985-R]
- Catedra Fundacion Antonio Aranzabal, Universidad de Navarra
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Balloon-occluded transarterial chemoembolisation (B-TACE) is an intraarterial transcatheter treatment for liver cancer. In B-TACE, an artery-occluding microballoon catheter occludes an artery and promotes collateral circulation for drug delivery to tumours. This paper presents a methodology for analysing the haemodynamics during B-TACE, by combining zero-dimensional and three-dimensional modelling tools. As a proof of concept, we apply the methodology to a patient-specific hepatic artery geometry and analyse two catheter locations. Results show that the blood flow redistribution can be predicted in this proof-of-concept study, suggesting that this approach could potentially be used to optimise catheter location.
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