4.5 Article

Effect of soy milk consumption on glycemic status, blood pressure, fibrinogen and malondialdehyde in patients with non-alcoholic fatty liver disease: a randomized controlled trial

Journal

COMPLEMENTARY THERAPIES IN MEDICINE
Volume 44, Issue -, Pages 44-50

Publisher

CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ctim.2019.02.020

Keywords

Soy milk; Non-alcoholic fatty liver disease; Insulin resistance; Blood pressure

Funding

  1. Vice Chancellor for Research, Iran University of Medical Sciences, Tehran, Iran

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Objective: Diet plays a critical role in the management of non-alcoholic fatty liver disease (NAFLD). Studies on the NAFLD's experimental models have reported that soy had positive effects on the improvement of metabolic parameters. However, there is a lack of clinical trials regarding the efficacy of whole soy foods. Therefore, this study was conducted to determine the effect of soy milk on some of the metabolic characteristics in patients with NAFLD. Methods: Sixty-sex patients diagnosed with NAFLD were included in this randomized, parallel, controlled trial and were randomly assigned to either the soy milk or control group. Both groups received a 500-deficit calorie diet plan. Also, patients in the soy milk group consumed 240 ml/day soy milk for 8 weeks. Fasting blood sugar (FBS), serum insulin, HOMA-IR, HOMA-beta%, and QUICKI as well as serum malondialdehyde (MDA), plasma fibrinogen, and blood pressure (BP) were measured at the beginning and end of the study. Results: After 8-weeks of intervention, soy milk group had a greater significant reduction in serum insulin (-3.44 +/- 5.02 vs. -1.09 +/- 3.77 mu IU/ml, P = 0.04), HOMA-IR (-0.45 +/- 0.64 vs -0.14 +/- 0.47, P = 0.03), systolic (-3.81 +/- 4.15 vs -1.48 +/- 2.93 mmHg, P = 0.01) and diastolic (-2.39 +/- 2.80 vs. -0.94 +/- 2.76 mmHg, P = 0.04) BP, and also, a significant increase in QUICKI (0.02 +/- 0.032 vs. 0.008 +/- 0.018, P = 0.04) compared to the control group. While, changes in the FBS, HOMA-beta%, fibrinogen, and MDA were not significantly different between the study groups. Conclusion: A low-calorie diet containing soy milk had beneficial effects on serum insulin, HOMA-IR, QUICKI, and BP in patients with NAFLD.

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